Dan Niculescu-Duvaz: search on Z-Library

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1

Novel Inhibitors of B-RAF Based on a Disubstituted Pyrazine Scaffold. Generation of a Nanomolar Lead

Niculescu-Duvaz, Ion, Roman, Esteban, Whittaker, Steven R., Friedlos, Frank, Kirk, Ruth, Scanlon, Ian J., Davies, Lawrence C., Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 209 KB

english, 2006

2

Novel Hinge Binder Improves Activity and Pharmacokinetic Properties of BRAF Inhibitors

Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M., Niculescu-Duvaz, Ion, Whittaker, Steven, Niculescu-Duvaz, Dan, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A., Lopes, Filipa, Preece

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.56 MB

english, 2010

3

Self-Immolative Nitrogen Mustard Prodrugs for Suicide Gene Therapy

Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Friedlos, Frank, Martin, Janet, Spooner, Robert, Davies, Lawrence, Marais, Richard, Springer, Caroline J.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 172 KB

english, 1998

4

Synthesis of Novel Cationic Lipids: Effect of Structural Modification on the Efficiency of Gene Transfer

Heyes, James A., Niculescu-Duvaz, Dan, Cooper, Robert G., Springer, Caroline J.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 226 KB

english, 2002

5

B-RAF is a therapeutic target in melanoma

Karasarides, Maria, Chiloeches, Antonio, Hayward, Robert, Niculescu-Duvaz, Dan, Scanlon, Ian, Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Martin, Jan, Marshall, Christopher J

Journal:

Year:

2004

Language:

english

File:

PDF, 339 KB

english, 2004

6

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships

Leung, Leo, Niculescu-Duvaz, Dan, Smithen, Deborah, Lopes, Filipa, Callens, Cedric, McLeary, Robert, Saturno, Grazia, Davies, Lawrence, Aljarah, Mohammed, Brown, Michael, Johnson, Louise, Zambon, Alfo

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 654 KB

2019

7

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships

Leung, Leo, Niculescu-Duvaz, Dan, Smithen, Deborah, Lopes, Filipa, Callens, Cedric, McLeary, Robert, Saturno, Grazia, Davies, Lawrence, Aljarah, Mohammed, Brown, Michael, Johnson, Louise, Zambon, Alfo

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 654 KB

english, 2019

8

Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds

Dan Niculescu-Duvaz, Ion Niculescu-Duvaz, Bart M.J.M. Suijkerbuijk, Delphine Ménard, Alfonso Zambon, Arnaud Nourry, Lawrence Davies, Helen A. Manne, Frank Friedlos, Lesley Ogilvie, Douglas Hedley, And

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.32 MB

english, 2010

9

Small molecule inhibitors of BRAF in clinical trials

Alfonso Zambon, Ion Niculescu-Duvaz, Dan Niculescu-Duvaz, Richard Marais, Caroline J Springer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 421 KB

english, 2012

10

Corrigendum to “A higher yielding synthesis of the clinical prodrug ZD2767P using di-protected 4-[N,N-bis(2-hydroxyethyl)amino]phenyl chloroformate”: [Tetrahedron Lett. 46 (2005) 6919]

Dan Niculescu-Duvaz, Ian Scanlon, Ion Niculescu-Duvaz, Caroline J. Springer

Journal:

Tetrahedron Letters

Year:

2006

File:

PDF, 44 KB

2006

11

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma

Girotti, Maria Romina, Lopes, Filipa, Preece, Natasha, Niculescu-Duvaz, Dan, Zambon, Alfonso, Davies, Lawrence, Whittaker, Steven, Saturno, Grazia, Viros, Amaya, Pedersen, Malin, Suijkerbuijk, Bart M.

Journal:

Year:

2015

Language:

english

File:

PDF, 4.00 MB

english, 2015

12

The EGF Receptor Hokey-Cokey

Dan Niculescu-Duvaz, Steven Whittaker, Caroline Springer, Richard Marais

Journal:

Year:

2007

Language:

english

File:

PDF, 199 KB

english, 2007

13

Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents

Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Davies, Lawrence, Pons, Jean-Francois, Whittaker, Steven, Marais, Richard, Springer, Caroline

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.23 MB

english, 2013

14

Corrections to Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF)

Niculescu-Duvaz, Dan, Gaulon, Catherine, Dijkstra, Harmen P., Niculescu-Duvaz, Ion, Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M., Nourry, Arnaud, Davies, Lawrence, Manne, Helen, Fri

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 558 KB

english, 2009

15

Novel Inhibitors of the v-raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) Based on a 2,6-Disubstituted Pyrazine Scaffold

Niculescu-Duvaz, Ion, Roman, Esteban, Whittaker, Steven R., Friedlos, Frank, Kirk, Ruth, Scanlon, Ian J., Davies, Lawrence C., Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 255 KB

english, 2008

16

Topical 5-Fluorouracil Elicits Regressions of BRAF Inhibitor–Induced Cutaneous Squamous Cell Carcinoma

Viros, Amaya, Hayward, Robert, Martin, Matthew, Yashar, Sharona, Yu, Clarissa C, Sanchez-Laorden, Berta, Zambon, Alfonso, Niculescu-Duvaz, Dan, Springer, Caroline, Lo, Roger S, Marais, Richard

Journal:

The Journal of Investigative Dermatology

Year:

2013

Language:

english

File:

PDF, 36 KB

english, 2013

17

Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow

Brown, Michael, Aljarah, Mohammed, Asiki, Hannah, Leung, Leo M. H., Smithen, Deborah A., Miller, Natalie, Nemeth, Gabor, Davies, Lawrence, Niculescu-Duvaz, Dan, Zambon, Alfonso, Springer, Caroline

Journal:

Organic Process Research & Development

Year:

2020

File:

PDF, 3.04 MB

2020

18

Potential anticancer agents. 10. Synthesis of N-[4-[[(2,4-diamino-7-pteridyl)methyl]-N10-methylamino]benzoyl)glutamic acid

Suster, Dan C., Feyns, Liviu V., Ciustea, Gheorghe, Botez, Georgeta, Dobre, Vasile, Bick, Ralph, Niculescu-Duvaz, Ion

Journal:

Journal of Medicinal Chemistry

Year:

1974

Language:

english

File:

PDF, 437 KB

english, 1974

19

C-end your drugs using peptide tags

Dan Niculescu-Duvaz, Caroline Springer, Richard Marais

Journal:

Pigment Cell & Melanoma Research

Year:

2010

Language:

english

File:

PDF, 121 KB

english, 2010

20

Development of Novel, Highly Potent Inhibitors of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF): Increasing Cellular Potency through Optimization of a Distal Heteroaromatic Group

Suijkerbuijk, Bart M. J. M., Niculescu-Duvaz, Ion, Gaulon, Catherine, Dijkstra, Harmen P., Niculescu-Duvaz, Dan, Ménard, Delphine, Zambon, Alfonso, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A.,

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.16 MB

english, 2010

21

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

Tang, HaoRan, Leung, Leo, Saturno, Grazia, Viros, Amaya, Smith, Duncan, Di Leva, Gianpiero, Morrison, Eamonn, Niculescu-Duvaz, Dan, Lopes, Filipa, Johnson, Louise, Dhomen, Nathalie, Springer, Caroline

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 3.14 MB

english, 2017

22

Novel Potent BRAF Inhibitors: Toward 1 nM Compounds through Optimization of the Central Phenyl Ring

Ménard, Delphine, Niculescu-Duvaz, Ion, Dijkstra, Harmen P., Niculescu-Duvaz, Dan, Suijkerbuijk, Bart M. J. M., Zambon, Alfonso, Nourry, Arnaud, Roman, Esteban, Davies, Lawrence, Manne, Helen A., Fri

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.67 MB

english, 2009

23

2-Aminomethylene-5-Sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth

Smithen, Deborah A, Leung, Leo, Challinor, Mairi, Lawrence, Rae, Tang, HaoRan, Niculescu-Duvaz, Dan, Pearce, Simon P, Mcleary, Robert, Lopes, Filipa, Aljarah, Mohammed, Brown, Michael, Johnson, Louise

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 936 KB

english, 2019

24

Self-Immolative Nitrogen Mustards Prodrugs Cleavable by Carboxypeptidase G2 (CPG2) Showing Large Cytotoxicity Differentials in GDEPT

Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Friedlos, Frank, Martin, Jan, Lehouritis, Panos, Marais, Richard, Springer, Caroline J.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 551 KB

english, 2003

25

BRAF Inhibitors Based on an Imidazo[4,5]pyridin-2-one Scaffold and a Meta Substituted Middle Ring

Nourry, Arnaud, Zambon, Alfonso, Davies, Lawrence, Niculescu-Duvaz, Ion, Dijkstra, Harmen P., Ménard, Delphine, Gaulon, Catherine, Niculescu-Duvaz, Dan, Suijkerbuijk, Bart M. J. M., Friedlos, Frank,

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.55 MB

english, 2010

26

BRAF as a therapeutic target: a patent review (2006 – 2012)

Zambon, Alfonso, Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Marais, Richard, Springer, Caroline J

Journal:

Expert Opinion on Therapeutic Patents

Year:

2013

Language:

english

File:

PDF, 391 KB

english, 2013

27

Self-Immolative Anthracycline Prodrugs for Suicide Gene Therapy

Niculescu-Duvaz, Ion, Niculescu-Duvaz, Dan, Friedlos, Frank, Spooner, Robert, Martin, Janet, Marais, Richard, Springer, Caroline J.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 64 KB

english, 1999

28

Potential anticancer agents. 17. Analogs of methotrexate with a tripeptide side chain

Suster, Dan Carol, Tarnauceanu, Eutanta, Botez, Georgeta, Dobre, Vasile, Niculescu-Duvaz, Ion

Journal:

Journal of Medicinal Chemistry

Year:

1978

Language:

english

File:

PDF, 350 KB

english, 1978

29

Long Functionalized Poly(ethylene glycol)s of Defined Molecular Weight: Synthesis and Application in Solid-Phase Synthesis of Conjugates

Niculescu-Duvaz, Dan, Getaz, Jayne, Springer, Caroline J.

Journal:

Bioconjugate Chemistry

Year:

2008

Language:

english

File:

PDF, 311 KB

english, 2008

30

Potential anticancer agents. 16. Methotrexate analogs with a modified peptide side chain

Suster, Dan Carol, Tarnauceanu, Eutanta, Ionescu, Dumitru, Dobre, Vasile, Niculescu-Duvaz, Ion

Journal:

Journal of Medicinal Chemistry

Year:

1978

Language:

english

File:

PDF, 505 KB

english, 1978

31

A higher yielding synthesis of the clinical prodrug ZD2767P using di-protected 4-[N,N-bis(2-hydroxyethyl)amino]phenyl chloroformate

Dan Niculescu-Duvaz, Ian Scanlon, Ion Niculescu-Duvaz, Caroline J. Springer

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 124 KB

english, 2005

32

Topical 5-Fluorouracil Elicits Regressions of BRAF Inhibitor–Induced Cutaneous Squamous Cell Carcinoma

Viros, Amaya, Hayward, Robert, Martin, Matthew, Yashar, Sharona, Yu, Clarissa C, Sanchez-Laorden, Berta, Zambon, Alfonso, Niculescu-Duvaz, Dan, Springer, Caroline, Lo, Roger S, Marais, Richard

Journal:

The Journal of Investigative Dermatology

Year:

2013

Language:

english

File:

PDF, 373 KB

english, 2013

33

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma

Girotti, Maria Romina, Lopes, Filipa, Preece, Natasha, Niculescu-Duvaz, Dan, Zambon, Alfonso, Davies, Lawrence, Whittaker, Steven, Saturno, Grazia, Viros, Amaya, Pedersen, Malin, Suijkerbuijk, Bart M.

Journal:

Year:

2017

Language:

english

File:

PDF, 668 KB

english, 2017

34

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

Paul T.C Wan, Mathew J Garnett, S.Mark Roe, Sharlene Lee, Dan Niculescu-Duvaz, Valerie M Good, Cancer Genome Project, C.Michael Jones, Christopher J Marshall, Caroline J Springer, David Barford, Richa

Journal:

Year:

2004

Language:

english

File:

PDF, 806 KB

english, 2004

35

Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF)

Niculescu-Duvaz, Dan, Gaulon, Catherine, Dijkstra, Harmen P., Niculescu-Duvaz, Ion, Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M., Nourry, Arnaud, Davies, Lawrence, Manne, Helen, Fri

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 208 KB

english, 2009

36

A Facile Synthesis of an Oxazolo[5,4]pyrimidin-2-one and a Pyrimido[5,4][1,3]oxazin-2-one

Dijkstra, Harmen, Gaulon, Catherine, Niculescu-Duvaz, Dan, Springer, Caroline

Journal:

Year:

2006

Language:

english

File:

PDF, 66 KB

english, 2006

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